barbfeick.com Blog


Vaccine patents with peanuts

Posted in Health, Peanut allergies by Administrator on the March 25th, 2009

I searched for vaccine patents that had peanut in the description. I found many with peanut oil as an ingredient. Treenuts are also a common allergy. I found other oils listed as possible ingredients which could account for treenut allergies in young children.

http://www.wipo.int/pctdb/en/wo.jsp?wo=1993021325&IA=WO1993021325&DISPLAY=DESC

WO 1993021325 19931028
WILD-TYPE MEASLES VIRUS GLYCOPROTEINS: VACCINE AND DETECTION METHOD THEREFOR
Background of the Invention
-
It is yet another object of the invention to provide a measles virus consensus hemagglutinin polypeptide in substantially pure form that possesses an amino acid sequence described by a consensus hemagglutinin formula herein.
It is a further another object of the invention to provide a measles virus consensus fusion polypeptide in substantially pure form which contains six amino acid substitutions, relative to the Moraten strain fusion protein, which are shared among at least two wild-types of measles virus….
A vaccine according to the present invention further comprises an adjuvant in order to increase the immunogenicity of the vaccine preparation. The adjuvant can be selected, for example, from Freund’s complete or incomplete adjuvant, aluminum hydroxide, a saponin, a muramyl dipeptide, an iscorn, a vegetable oil (li e peanut oil) or a mineral oil, such as silicone oil.

http://www.patentstorm.us/patents/5753234/description.html

US Patent 5753234 – Single-shot vaccine formulation
Exemplary injection media which can be used in the present invention include a buffer with or without dispersing agents and/or preservatives, an edible oil, mineral oil, cod liver oil, squalene, squalane, mono-, di- or triglyceride and a mixture thereof; said edible oil being corn oil, sesame oil, olive oil, soybean oil, safflower oil, cotton seed oil, peanut oil or a mixture thereof.

http://www.patentstorm.us/patents/6720001/claims.html

US Patent 6720001 – Emulsion compositions for polyfunctional active ingredients
1. A stabilized pharmaceutical oil-in-water emulsion for delivery of a polyfunctional drug, wherein the emulsion has a mean particle diameter of less than about 5 μm and consists essentially of:

(a) a therapeutically effective amount of a polyfunctional drug selected from the group consisting of analgesics, anti-inflammatory agents, anthelmintics, antiarrhythimic agents, anti-asthma agents, anti-bacterial agents, anti-viral agents, anti-coagulants, anti-depressants, anti-diabetic agents, anti-epileptic agents, anti-fungal agents, anti-gout agents, anti-hypertensive agents, anti-malarials, anti-migraine agents, anti-muscarinic agents, anti-neoplostic agents, immunosuppressants, anti-protozoal agents, anti-thyroid agents, anti-tussives, anxiolytics, sedatives, hypnotics, neuroleptic agents, β-blockers, cardiac inotropic agents, corticosteroids, diuretics, anti-parkinsonism agents, gastrointestinal agents, histamine receptor antagonists, keratolytics, lipid regulating agents, muscle relaxants, anti-anginal agents, sex hormones, stimulants, cytokines, peptidomimetics, proteins, peptides, toxoids, antibodies, vaccines, nucleosides, nucleotides, nucleic acids, DNA, RNA, oligonucleotides, oligodeoxynucleotides, and combinations thereof;

(b) an aqueous phase;

(c) an oil phase consisting essentially of…
8. The pharmaceutical emulsion of claim 1, wherein the oil phase further comprises almond oil; babassu oil; borage oil; black currant seed oil; canola oil; castor oil; coconut oil; corn oil; cottonseed oil; emu oil; evening primrose oil; flax seed oil; grapeseed oil; groundnut oil; mustard seed oil; olive oil; palm oil; palm kernel oil; peanut oil; rapeseed oil; safflower oil; sesame oil; shark liver oil; soybean oil; sunflower oil; hydrogenated castor oil; hydrogenated coconut oil; hydrogenated palm oil; hydrogenated soybean oil; hydrogenated vegetable oil; a mixture of hydrogenated cottonseed oil and hydrogenated castor oil; partially hydrogenated soybean oil; a mixture of partially hydrogenated soybean oil and partially hydrogenated cottonseed oil; glyceryl trioleate; glyceryl trilinoleate; glyceryl trilinolenate; a Ω3 polyunsaturated fatty acid triglyceride containing oil; or a mixture thereof.

9. The pharmaceutical composition of claim 1, wherein the oil phase further comprises coconut oil; corn oil; olive oil; palm oil; peanut oil; safflower oil; sesame oil; soybean oil; hydrogenated castor oil; hydrogenated coconut oil; partially hydrogenated soybean oil; glyceryl trioleate; glyceryl trilinoleate; glyceryl trilinolenate; a Ω3 polyunsaturated fatty acid triglyceride containing oil; or a mixture thereof.

10. The pharmaceutical composition of claim 1, wherein the oil phase further comprises corn oil; olive oil; palm oil; peanut oil; safflower oil; sesame oil; soybean oil; hydrogenated castor oil; partially hydrogenated soybean oil; glyceryl trioleate; glyceryl trilinoleate; a Ω3 polyunsaturated fatty acid triglyceride containing oil; or a mixture thereof.

http://www.faqs.org/patents/app/20080199491

Patent title: Sustained Release Vaccine Composition
88. A non-liquid vaccine composition according to claim 87, including a component active against one or more disease pathogens selected from the group consisting of Adenovirus, AIDS, Anthrax, BCG, Chlamydia, Cholera, Circovirus, Classical swine fever, Coronavirus, Diphtheria-Tetanus, Distemper virus, DTaP, DTP, E coli, Eimeria (coccidosis), Encephalitis, Feline immunodeficiency virus, Feline leukemia virus, Foot and mouth disease, Hemophilus, Hepatitis A, B,C,D,E,F, Hepatitis B/Hib, Herpes virus, Hib, Influenza, Japanese Encephalitis, Lyme disease, Measles, Measles-Rubella, Meningococcal, MMR, Mumps, Mycoplasma, Para influenza virus, Parvovirus, Pasteurella, Pertussis, Pestivirus, Plague, Pneumococcal, Polio (IPV), Polio (OPV), Pseudorabies, Rabies, Respiratory syncitial virus, Rhinotracheiitis, Rotavirus, Rubella, Salmonella, SARS, Tetanus, Typhoid, Varicella, Viral diarrhoea virus, Yellow Fever. …
[0049]In certain embodiments, the vaccine composition may include other adjuvants, including adjuvants in liquid form. Such other adjuvants that may be used include squalene and squalene, Adjuvant 65 (containing peanut oil, mannide monooleate and aluminium monostearate), surfactants such as hexadecylamine, octadecylamine, lysolecithin, dimethyl-dioctadecylammonium bromide, N,N-dioctradecyl-N,N.sup.1-bis(2-hydroxyethyl)-propanediamine, methoxy-hexadecylglycerol and pluronic polyols, polyanions such as pyran, dextran sulfate, polyacrylic acid and carbopol, peptides and amino acids such as muramyl dipeptide, demethylglycine, tuftsin and trehalose dimycolate, Adju-Phos, Algal Glucan, Algammulin, aluminium salts including aluminium hydroxide (Al(OH).sub.3), aluminium phosphate (AlPO.sub.4), Alhydrogel, Antigen Formulation, Avridine, Bay R1005, Calcitriol, Calcium Phosphate, Calcium Phosphate Gel, Cholera Holotoxin (CT), Cholera Toxin B Subunit (CTB), CRL1005, DDA, DHEA, DMPC, DMPG, DOC/Alum Complex, Gamma Inulin, Gerbu Adjuvant, GMDP, Imiquimod, ImmTher, Interferon-gamma, Iscoprep 7.0.3, Loxoribine, LT-OA or LT Oral Adjuvant, MF59, Mannan, MONTANIDE ISA 51, MONTANIDE ISA 720, MPL, MTP-PE, MTP-PE, Murametide, Murapalmitine, D-Murapalmitine, NAGO, Nonionic Surfactant Vesicles, Pleuran, PLGA, PGA and PLA, Pluronic L121, PMMA, PODDS, Poly Ra: Poly rU, Polyphosphazene, Polysorbate 80, Protein Cochleates, QS-21, Quil A, Rehydragel HPA, Rehydragel LV, S-28463, SAF-1, Sclavo Peptide, Sendai Proteoliposomes, Sendai-Containing Lipid Matrices, Span 85, Specol, Stearyl Tyrosine, Theramide, Threonyl-MDP and Ty Particles.

http://www.freepatentsonline.com/EP1742656.html

NOVEL PEANUT SKIN EXTRACT AS A VACCINE ADJUVANT
Abstract not available for EP1742656
Abstract of corresponding document: WO2005089262
The present invention relates to a novel adjuvant and/or immunomodulator isolated from peanut skin extract, which may be useful in the preparation of immunogenic compositions and vaccines. The present invention also provides for a method of stimulating acquisition of protective immunity by administering peanut skin extract prior to vaccination.

http://www.freepatentsonline.com/EP1154792.html

TUBERCULOSIS VACCINE FORMULATION COMPRISING MONOGLYCERIDES OR FATTY ACIDS AS ADJUVANT
…The TB vaccine composition according to the invention may further comprise pharmaceutical excipients selected from the group consisting of biocompatible oils, such as rape seed oil, sunflower oil, peanut oil, cotton seed oil, jojoba oil, squalan or squalene, physiological saline solution, preservatives and osmotic pressure controlling agents, carrier gases, pH-controlling agents, organic solvents, hydrophobic agents, enzyme inhibitors, water absorbing polymers, surfactants, absorption promoters, and anti-oxidative agents….

http://www.freepatentsonline.com/5679356.html

Use of GM-CSF as a vaccine adjuvant
…To obtain a stronger humoral and/or cellular response, it is common to administer a vaccine in a formulation containing an adjuvant. An adjuvant is a substance that enhances, nonspecifically, the immune response to an antigen, or which causes an individual to respond to an antigen who would otherwise without the adjuvant not respond to the antigen. An adjuvant is usually administered with an antigen, but may also be given before or after antigen administration. Suitable adjuvants for the vaccination of mammals include but are not limited to Adjuvant 65 (containing peanut oil, mannide monooleate and aluminum monostearate); Freund’s complete or incomplete adjuvant; mineral gels such as aluminum hydroxide, aluminum phosphate and alum; surfactants such as hexadecylamine, octadecylamine, lysolecithin, dimethyldioctadecyl-ammonium bromide, N,N-dioctadecyl-N’,N’-bis(2-hydroxymethyl) propanediamine, methoxyhexadecylglycerol and pluronic polyols; polyanions such as pyran, dextran sulfate, poly IC, polyacrylic acid and carbopol; peptides such as muramyl dipeptide, dimethylglycine and tuftsin; and oil emulsions. The antigens could also be administered following incorporation into liposomes or other microcarriers….

______________________________________
Formulation 2 INGREDIENTS
______________________________________

Lyopilized GM-CSF 10-1000 mcg
Water-for-injection for reconstitution
0.2 ml
Dioctyl Sodium Sulfosuccinate
1 mg
Peanut oil for emulsion
2 ml
Peanut oil for gel 2 ml
Aluminum monostearate 50 mg
To prepare the sustained release preparation of GM-CSF according to Formulation 2, the aluminum monostearate is mixed into the peanut oil for the gel and heat elevated to form the gel according to known methods.
The dioctyl sodium sulfosuccinate is dissolved into the Water for Injection. The lyophilized GM-CSF is reconstituted with the dioctyl sodium sulfosuccinate solution, the resultant solution is transfered into the peanut oil for emulsion and mixed by vortexing. The resultant emulsion is then mixed into the previously prepared gelled peanut oil and mixed by vortexing.
…To obtain a stronger humoral and/or cellular response, it is common to administer a vaccine in a formulation containing an adjuvant. An adjuvant is a substance that enhances, nonspecifically, the immune response to an antigen, or which causes an individual to respond to an antigen who would otherwise without the adjuvant not respond to the antigen. An adjuvant is usually administered with an antigen, but may also be given before or after antigen administration. Suitable adjuvants for the vaccination of mammals include but are not limited to Adjuvant 65 (containing peanut oil, mannide monooleate and aluminum monostearate); Freund’s complete or incomplete adjuvant; mineral gels such as aluminum hydroxide, aluminum phosphate and alum; surfactants such as hexadecylamine, octadecylamine, lysolecithin, dimethyldioctadecyl-ammonium bromide, N,N-dioctadecyl-N’,N’-bis(2-hydroxymethyl) propanediamine, methoxyhexadecylglycerol and pluronic polyols; polyanions such as pyran, dextran sulfate, poly IC, polyacrylic acid and carbopol; peptides such as muramyl dipeptide, dimethylglycine and tuftsin; and oil emulsions. The antigens could also be administered following incorporation into liposomes or other microcarriers….

http://www.freepatentsonline.com/4806350.html

Vaccine formulation
DETAILED DESCRIPTION OF THE INVENTION

The vaccine formulation of the invention employs a saponin and an oil as an adjuvant. It is a parenterally administerable mono- or polyvalent vaccine in which the antigen is any antigen or antigenic component for stimulating a desired immune response. Such vaccine can be, for example, a vaccine for protecting a mammal against infection, or against development of a disease state resulting from infection, by a pathogenic or opportunistic bacteria, virus, parasite or other invasive microbe or organism. Such vaccine can also be, for example, a hormone such as leutenizing hormone. In the former case, the antigen can be one or more modified or inactivated bacteria, viruses, parasites or other microbes or organisms or one or more subunits thereof or derivatives of such subunits.
The vaccine is formulated to comprise a vaccinal amount, that is, an effective, non-toxic amount of each antigen per dose in accordance with standard procedures for vaccine preparation employing an O/W or W/O emulsion. Typically, this comprises adding an immunostimulating antigen and a saponin to the oil or water phase of an oil and water emulsion prior to combining the oil and water. Usually, the antigen and saponin are added to the water. A saponin is typically added to the aqueous phase in an amount of 15 to 5000 micrograms, preferably 25 to 1000 micrograms, per dose. Any of the saponins or saponin derivatives can be used. See, e.g., Charlier et al., Arch. Exp. Vet.-Med. 27: 783 (1973) and Bonati, U.S. Pat. No. 4,101,652. Preferably, such saponin has lipophilic and hydrophilic regions and therefore can function as a surfactant and emulsifier. Quil A is the preferred saponin. Quil A forms micelles in aqueous solutions at concentrations as low as 0.03% and forms complexes with a wide range of antigens. It is publicly available from a variety of sources including commercial vendors, such as Superfos (Copenhagen, Denmark).
The oil phase comprises one or more parenterally tolerated oils. These include vegetable oil such as soy bean oil and peanut oil, mineral oils, such as Drakeol 6VR, animal oils such as squalene, and intermediate length (C12 to C20) alkanes, optionally substituted, such as hexadecane. See, for example, Murray et al., Ann. Allergy 30: 146 (1972). The amount of oil is up to 95% by volume. In O/W emulsions, the amount of oil is preferably 0.2 to 20%, more preferably 0.5 to 10% and in W/O emulsions the amount of oil is preferably 40 to 90%, more preferably 50 to 70%.

http://www.freepatentsonline.com/7459163.html

Infectious DNA as a vaccine against west nile and other flaviviruses
…The term “carrier” refers to a diluent, adjuvant, excipient, or vehicle with which the attenuated virus or infectious DNA is administered. Such pharmaceutical carriers can be sterile liquids, such as water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. Suitable pharmaceutical excipients include starch, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, sodium stearate, glycerol monostearate, talc, sodium chloride, dried skim milk, glycerol, propylene, glycol, water, ethanol and the like. The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. These compositions can take the form of solutions, suspensions, emulsion, tablets, pills, capsules, powders, sustained-release formulations and the like. The composition can be formulated as a suppository, with traditional binders and carriers such as triglycerides. Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, etc. Examples of suitable pharmaceutical carriers are described in “Remington’s Pharmaceutical Sciences” by E. W. Martin….

http://www.freepatentsonline.com/5874085.html

Vaccine for enhanced production of IgA antibodies
…Any pharmaceutically acceptable carrier can be employed for the multivalent antigen receptor crosslinker, CD40 ligand, TGF-β, IL-4, and either IL-5 or IL-2. Carriers can be sterile liquids, such as water, oils, including petroleum oil, animal oil, vegetable oil, peanut oil, soybean oil, mineral oil, sesame oil, and the like. With intravenous administration, water is a preferred carrier. Saline solutions, aqueous dextrose, and glycerol solutions can also be employed as liquid carriers, particularly for injectable solutions. Suitable pharmaceutical carriers are described in Remington’s Pharmaceutical Sciences, 18th Edition (A. Gennaro, ed., Mack Pub., Easton, Pa., 1990), incorporated by reference….

http://www.freepatentsonline.com/5709879.html

Vaccine compositions containing liposomes
…Sources for vegetable oils include nuts, seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil, the most commonly available, exemplify the nut oils. Seed oils include safflower oil, cottonseed oil, sunflower seed oil, sesame seed oil and the like. In the grain group, corn oil is the most readily available, but the oil of other cereal grains such as wheat, oats, rye, rice, teff, triticale and the like may also be used….

http://www.freepatentsonline.com/6890540.html

Vaccine formulation
…The vaccine formulation according to the invention may further comprise pharmaceutical excipients selected from the group consisting of biocompatible oils, such as such as rape seed oil, sunflower oil, peanut oil, cotton seed oil, jojoba oil, squalan or squalene, physiological saline solution, preservatives and osmotic pressure controlling agents, carrier gases, pH-controlling agents, organic solvents, hydrophobic agents, enzyme inhibitors, water absorbing polymers, surfactants, absorption promoters, and anti-oxidative agents….

http://www.freepatentsonline.com/7361352.html

Influenza immunogen and vaccine
…Vaccines or inocula are typically prepared from a recovered recombinant HBc chimer immunogen particles by dispersing the particles in a physiologically tolerable (acceptable) diluent vehicle such as water, saline phosphate-buffered saline (PBS), acetate-buffered saline (ABS), Ringer’s solution or the like to form an aqueous composition. The diluent vehicle can also include oleaginous materials such as peanut oil, squalane or squalene as is discussed hereinafter….
…Another particularly preferred adjuvant for use with an immunogen of the present invention is an emulsion. A contemplated emulsion can be an oil-in-water emulsion or a water-in-oil emulsion. In addition to the immunogenic chimer protein particles, such emulsions comprise an oil phase of squalene, squalane, peanut oil or the like as are well known, and a dispersing agent. Non-ionic dispersing agents are preferred and such materials include mono- and di-C12-C24-fatty acid esters of sorbitan and mannide such as sorbitan mono-stearate, sorbitan mono-oleate and mannide mono-oleate. An immunogen-containing emulsion is administered as an emulsion….

http://www.freepatentsonline.com/7153513.html

West nile vaccine
Suitable adjuvants can include immunostimulating oils such as certain metabolizable oils. Metabolizable oils suitable for use in the composition of the invention include oil emulsions, e.g., SP oil (hereinafter described), Emulsigen (MPV Laboratories, Ralston, NZ), Montanide 264,266,26(Seppic SA, Paris, France), as well as peanut oil and other vegetable-based oils, squalane (shark liver oil) or other metabolizable oil which can be shown to be suitable as an adjuvant in veterinary vaccine practice.

http://www.freepatentsonline.com/5814321.html

Oil adjuvant vaccine and method for preparing same

EMBODIMENTS OF THE INVENTION

The component A) of the oil adjuvant vaccine according to the present invention is an oil component which is in a liquid state at ordinary temperature. The term “ordinary temperature” used herein means a temperature falling within the range of from 15° to 25° C.
The oil component which is in a liquid state at ordinary temperature and which can be used in the present invention may variously be selected from ester type oil bases or non-ester type oil bases which have commonly been used in, for instance, foods, drugs and cosmetics and which are in a liquid state at ordinary temperature. Examples of non-ester type oil bases which are in a liquid state at ordinary temperature include light liquid paraffins, squalene, squalane and polybutenes. In addition, examples of ester type oil bases which are in a liquid state at ordinary temperature include various esters derived from medium chain saturated fatty acids such as caprylic acid and capric acid or long chain unsaturated fatty acids such as oleic acid and linoleic acid, and alcohols; naturally occurring fatty acid esters, for instance, liquid vegetable oils such as peanut oil, olive oil, sunflower seed oil, safflower oil and jojoba oil and liquid oils originated from animals such as orange roughy oil, which may be used alone or in combination depending on the purposes. Oils such as ester derivatives of oleic acid and vegetable oils, among others, have various advantages such that they are relatively high stability to oxidation, they have high affinity to organ-tissues and their local stimulation and remaining-tendency can be reduced and therefore, it is preferred to use at least one member selected from only these metabolizable oils as the oil component. Moreover, it is particularly prefered to use an ester type oil base comprising an ester derived from a fatty acid, which comprises not less than 85% by weight of cis-Δ9-octadecenoic acid and not less than 90% by weight of cis-Δ9-alkenoic acids, and an alcohol such as glycerol, diglycerol, propylene glycol, ethyl alcohol, decyl alcohol and oleyl alcohol which comprises not less than 85% by weight of cis-Δ9-octadecenol and not less than 90% by weight of cis-Δ9-alkenols. Alternatively, it is also possible in the present invention to use a mixture of the foregoing ester type oil(s) with squalene.

http://www.freepatentsonline.com/4073743.html

Process for preparing an emulsion
The specific oil employed in the adjuvant composition of the invention is not critical. Any physiologically acceptable injectable oil or mixtures thereof including those oils which satisfy the specifications of the United States Pharmacopeia or National Formulary may be utilized in the practice of the invention. Representative members include peanut oil, safflower oil, soya bean oil, cottonseed oil, mineral oils of a pharmaceutical grade such as light liquid paraffin and light mineral oil, chaulmoogra oil, corn oil, persic oil, olive oil, sesame oil, almond oil, castor oil, squalane, isopropyl myristate and coconut oil. Of particular preference are peanut oil and highly purified light mineral oil….
The proportion of the oil and the aqueous phases in the emulsion may vary over a wide range, however, an effective adjuvant composition may be achieved utilizing from about 42.5 to about 48% of oil phase, from about 2 to about 7.5% fatty acid metal salt and isomannide monooleate and from about 45 to about 55% of aqueous phase by volume wherein in the selected composition the sum of the components is always 100%. The preferred composition contains about 50% (inclusive of the fatty acid metal salt and isomannide monooleate) by volume of oil phase and about 50% of aqueous phase by volume, wherein the preferred composition of the oil phase is about 89.0% of oil, such as peanut oil, about 6.7% isomannide monooleate and about 4.3% aluminum monostearate by weight. The isomannide monooleate is highly purified, about 80% pure or higher, i.e., about 90% or above. For human vaccines, it is preferred to use C.P. grade (better than 98%)….
..wherein the oil phase is composed of peanut oil USP 89.5% by weight, isomannide monooleate C.P…

http://www.freepatentsonline.com/EP1097721.html

Oil-based adjuvant vaccine
…The non-ester oil base which becomes liquid at room temperature may be, for example, hydrocarbon such as light liquid paraffin, squalene, squalane, polybutene and the like, fatty acid such as saturated middle chain fatty acid (e.g., caprylic acid, capric acid and the like), long chain unsaturated fatty acid (e.g., oleic acid, linolic acid, linolenic acid and the like), middle chain or long chain aliphatic alcohol and the like. Examples of the ester oil base which is liquid at room temperature include various fatty acid esters derived from saturated middle chain fatty acid such as caprylic acid and capric acid, or unsaturated long chain fatty acid such as oleic acid and linolic acid and alcohol, as well as naturally occurring fatty acid esters, such as liquid vegetable oil (e.g., peanut oil, olive oil, safflower oil, sunflower oil, jojoba oil and the like), a liquid oil from animals, such as orange roughy oil, and the like.

http://www.freepatentsonline.com/EP0640348.html

Oil-based and water-based adjuvant mixture.
Sources for vegetable oils include nuts, seeds and grains. Peanut oil, soybean oil, coconut oil, and olive oil, the most commonly available, exemplify the nut oils. Seed oils include safflower oil, cottonseed oil, sunflower seed oil, sesame seed oil and the like. In the grain group, corn oil is the most readily available, but the oil of other cereal grains such as wheat, oats, rye, rice, teff, triticale and the like may also be used…

http://www.freepatentsonline.com/4158054.html

Preparation of virus sub-unit vaccines
…16. A process as claimed in claim 12 in which the adjuvant is an emulsion of water in peanut oil containing sorbitan tri-oleate as emulsifier and aluminium monostearate as stabliser…
…Alternatively, the antigens may, after removal of surfactant, be adjuvanted with other convenient adjuvants such as oil emulsions e.g. emulsions of water in an oily fatty acid glyceride such as peanut oil. Such emulsions may contain non-ionic emulsifiers such as sorbitan tri-oleate and a stabiliser such as aluminum monostearate….

One Response to 'Vaccine patents with peanuts'

Subscribe to comments with RSS or TrackBack to 'Vaccine patents with peanuts'.

  1. Amy S. said,

    on July 9th, 2009 at 4:18 pm

    Fantastic job researching. It is quite mind blowing.

Leave a Reply

You must be logged in to post a comment.