"Researchers at
Georgetown University Medical
Center have found that chronic
fatigue syndrome (CFS) may be rooted in distinct
neurological abnormalities that can be medically tested. Although the
sample studied was small, this research provides objective, physiological
evidence that the controversial disorder can be considered a legitimate
medical condition....
"The Georgetown study, published in
the November edition of the BMC Neurology
Journal, an online publication, reveals that patients diagnosed with CFS
and its family of illnesses have a set of proteins in their spinal cord
fluid that were not detected in healthy individuals. These proteins might
give insight into the causes of CFS and could someday be used as markers
to diagnose patients with the disorder.
""For years, patients with chronic fatigue
syndrome have suffered from painful symptoms for which there is no blood
test, diagnosable physical condition or any method for doctors to measure
improvement," said James Baraniuk, MD, assistant professor of
medicine at Georgetown University Medical Center and first author on the
study. "Our research provides initial evidence that chronic fatigue
syndrome and its family of illnesses may be legitimate, neurological
diseases and that at least part of the pathology involves the central
nervous system."
"The disorder is characterized by profound fatigue
that is not improved by bed rest and that may get worse with physical or
mental activity, according to the Centers for Disease Control and
Prevention. Persons with CFS usually function at a lower level of activity
than they were capable of before the onset of illness, feeling too tired
to perform normal activities or easily exhausted with no apparent reason.
Patients also report various nonspecific symptoms, including weakness,
muscle pain, impaired memory and/or mental concentration, insomnia and
post-exertional fatigue lasting more than 24 hours.
"The study looked at 50 individuals suffering from
at least two disorders related to CFS, including fibromyalgia and Gulf War
syndrome. By examining spinal cord fluid in patients with CFS and in
healthy individuals, the researchers found that CFS patients have 16
proteins that healthy individuals do not. Five of these 16 proteins are
found in all patients with the illnesses but in none of the controls. The
results indicate that those 16 proteins could possibly serve as a "biosignature"
for the disease and could someday be used to diagnose CFS."
http://www.sciencedaily.com/releases/2006/01/060110013424.htm