I found this interesting. I am over the CFS but not over my magnesium deficiency. I find that I need to take mega amounts. I dowse and find 10-12 pills per day would benefit me. I haven't taken that amount but have taken more than double the recommended dosage on the bottles.
The one exception is magnesium, which has been demonstrated
to be the single most effective treatment of CFS. It was demonstrated that
CFS sufferers are significantly deficient in magnesium (shown by red cell
magnesium levels) compared to healthy controls, and that parenteral
administration of magnesium was significantly helpful in 80% of patients
. At present it is unclear whether magnesium deficiency is part of the
cause of the condition or a result. However, as oral magnesium is relatively
ineffective, it would appear that reduced absorption and/or increased
excretion is probably the cause.
Patients with yeast overgrowth appear to be particularly susceptible to magnesium deficiency, possibly because the yeasts themselves extract magnesium from the diet and interfere more directly with absorption.
Some patients respond only slowly and temporarily to magnesium supplementation. Recent research has shown high excretion to be probably responsible for this, which in turn is due to a reduced level of intracellular glutathione peroxidase, an enzyme with the trace element selenium as a constituent. When this is reduced magnesium ‘leaks’ across the cell membrane into the serum and is hence excreted in the urine. Selenium supplements should therefore be taken by those on magnesium supplementation, particularly if they are vegetarian, as meat is the main source of dietary selenium.