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History Timeline of Vaccines & Food Allergies

  Allergies            Increase in the Number of Childhood Vaccines            Note this  

Vaccines # Recommended/notes  
  By the 1840's peanut oil was common in the US. And it was cheaper than olive oil.  
1879  First vaccine for cholera

1890  First vaccine for tetanus

1896  First vaccine for typhoid fever

1897  First vaccine for bubonic plague
1896 - An antibacterial, heat-labile serum component (complement) is described (Jules Bordet) 1891 - Demonstration of cutaneous (delayed type) hypersensitivity (Robert Koch)
1901 [Hmmm... "Lathman medium derive from bovine casein (cow’s milk) is used as a vaccine culture media." - bfg] The first case report of food allergy (cows' milk allergy) was published by Hamburger in 1901.
1902 1902 - Immediate hypersensitivity anaphylaxis (Paul Portier) and (Charles Richet)

1903 - Intermediate hypersensitivity, the "Arthus reaction" (Maurice Arthus)
1905 - "Serum sickness" allergy (Clemens von Pirquet and (Bela Schick)
1913 Charles Richet "In 1913, he was awarded the Nobel Prize for his researches on anaphylaxis. He invented this word to designate the sensitivity developed by an organism after it had been given a parenteral injection of a colloid or protein substance or a toxin (1902). Later he demonstrated the facts of passive anaphylaxis and anaphylaxis in vitro. The applications of anaphylaxis to medicine are extremely numerous. "
1917  Cholera vaccine

1917  Typhoid vaccine (parenteral)
1919 1919 PRESENT STATUS OF PNEUMOCOCCUS VACCINE Russell L. Cecil. Am J Public Health (N Y). 1919 August; 9(8): 589–592. ‘In this experiment we decided to substitute a pneumococcus lipovaccine for the saline vaccine which we had used at Camp Upton. This vaccine was prepared for us by Col. E.’ R. Whitmore of the Army Medical School, and the dose finally adopted after some preliminary experiments was 30 billion pneumococci (10 billion of each of the fixed types in one cc. of oil).  
1920   At Google books, the “Peanut Allergy Answer” book says  1920 was the first reference of a nut allergy.
1921  First vaccine for diphtheria

1926  First vaccine for pertussis (whooping cough)

1927  First vaccine for tuberculosis
  The pertussis vaccine's ability to kill was first signaled in 1933 when T. Madsen reported two babies died within minutes of vaccination.
1934   Dr. Vaughan studied an entire village of 508 people who lived in and around Clover, Virginia ..which meant that 60 percent of the population studied, had some degree of allergy....Out of the 60 percent of people who had major and minor allergies who where were able to attribute symptoms to definite causes…”62.6 percent reacted to foods..”14
1935  Yellow Fever vaccine

1945  First vaccine for influenza, Peanut oil and beeswax was added to penicillin injections
Refined cottonseed oil was a primary excipient in the injected "wonder drug" antibiotics and in vaccines. Lulled perhaps by medical advance, officials were surprised by the second mass allergic phenomenon that began in the 1930s. This was the first outbreak of food anaphylaxis in history and it was caused by just one food: cottonseed oil.
  When the first case of sesame allergy was reported in 1950, the allergen was considered anything but ordinary.
1952  First vaccine for polio

1955  Inactivated polio vaccine licensed
1958   First diagnosed case of semen allergy
children received on average one or two vaccines Van Thiel et al. [3] reported the first case of anisakiasis, in the Netherlands in 1960. (gastrointestinal Anisakis allergy)
1961  Monovalent oral polio vaccine licensed.

1963  Trivalent oral polio vaccine licensed

1964  First vaccine for measles

1967  First vaccine for mumps

1968-69  Rubella vaccine licensed

1970  First vaccine for rubella 
1970  Anthrax vaccine manufactured by the Michigan Department of Public Health
1971  Measles, Mumps, Rubella vaccine licensed (MMR).

1971  Routine smallpox vaccination ceases in the United States.

1974  First vaccine for chicken pox
1976   At Google books, the “Peanut Allergy Answer” book says  that there was no research in the field of peanut allergy until 1976.
1977  First vaccine for pneumonia (Streptococcus pneumoniae)

1978  First vaccine for meningitis (Neisseria meningitidis)

1978  the CDC added the triple shot MMR (measles, mumps, rubella) to the growing baby immunization program.

1978  Fluzone, the current flu vaccine that is made by Aventis pasteur, was licensed.
children received 8-9 vaccines Allergy to latex rubber was almost unknown before 1980, with only two cases described in medical literature, (stopper in vaccine vials)
1980  Meningococcal polysaccharide vaccine, groups A, C, Y, W135 combined (Menomune)
  In the 1970s very little allergy to kiwi fruit was reported; however reactions were increasingly reported in the 1980s, predominantly in adults.
  the prospective UCLA/FDA study published in Pediatrics in 1981 comparing DT and DPT vaccines would find that 1 in 875 DPT shots is followed by either a convulsion or collapse shock episode within 48 hours of vaccination.
1982  Hepatitis B vaccine becomes available.
1983  Pneumococcal vaccine, 23 valent
  The rapid increase in nut allergy has been quite alarming especially when one considers that Dr Hide described the first case of Brazil nut anaphylaxis in the UK as recently as 1983.
1985  The FDA gave a license to Praxis Biologicals for the first HIB vaccine for use in 24 month old children and, shortly after, Lederle and Connaught also were given licenses to manufacture HIB vaccine.

1986 The National Childhood Vaccine Injury Act (NCVIA) no manufacturer "shall be liable in any civil action" for any injury that "resulted from side effects that were unavoidable even though the vaccine was properly prepared and was accompanied by proper directions and warnings."
1986  Licensure of first recombinant vaccine (hepatitis B)    
1988   At Google books, the “Peanut Allergy Answer” book says - In 1988 four people died of peanut allergy.
1989  Two-dose measle vaccine recommendation

1989  Licensure of first polysaccharide conjugate vaccine (Haemophilus influenzae type b) for routine vaccination at 15 months
...the Centers for Disease Control mandated that vaccines increase. Vaccines increased from 10 to 24  
1990  Licensure of polysaccharide conjugate vaccine (Haemophilus influenzae type b) for routine vaccination at 2 months
children were routinely given 10 vaccinations  

1991  Universal infant hepatitis B vaccination recommended for all infants

1991  Acellular pertussis vaccine (DTaP) licensed for use in older children aged 15 months to six years old.

1993  Japanese encephalitis vaccine
"Bush government took action on a goal of raising national vaccination levels among preschool children to 90% by the year 2000."

By 1991. more than 17 million doses of Hib were sold in the US alone..."blockbuster product"
1994   According to the journal, the first known case of lupin allergy
1995  Varicella vaccine licensed

1995  Hepatitis A vaccine licensed.

1996  Acellular pertussis vaccine licensed for infants
1997  Sequential polio vaccination recommended   1 in 250 young children had peanut allergy in the US

The incidence of food allergy in children is approximately 1.3% and among adults 0.3% according to Chandra (1997).

According to Statistics Canada, there were 6 deaths due to food anaphylaxis in 1997

first known case of allergy to ingested pectin. A 3 1/2-year-old boy developed anaphylaxis once after eating Cashew nut and later after eating a pectin-containing fruit “smoothie”.
1998   This is the first known report of allergy to the tropical fruit rambutan
1999  First rotavirus vaccine licensed.
1999  - In five years from now, peanut allergy DOUBLES!
Combination vaccines: To complete the 1999 Recommended Childhood Schedule in the United States,1,2 a minimum of 13 separate injections are needed to immunize a child from birth to age six years, using vaccines licensed in the United States as of April 10, 1999.
Approximately 125 people die each year in the USA secondary to food-induced anaphylaxis. 80
2000  Pneumococcal conjugate vaccine (Prevnar) recommended for all young children.
Children now receive 33 vaccines before they enter school – a huge increase. 
Global vaccine sales doubled during the 1990s, from $2.9 billion in 1992 to more than $6 billion in 2000
2002 The Homeland Security Act  provided protection for vaccine manufacturers
2002   1 in 125 young children had peanut allergy in the US O’Brien tells IB News “That year there was a 50 percent increase in soy allergies that year alone in children and adults.  From 1997 to 2002 within five years of the introduction of GE soy peanut allergies doubled.”

In France, according to Le réseau d'allergovigilance, by Gisèle Kanny, Médecine Interne, Immunologie Clinique et Allergologie, Hôpital Central 54035 Nancy cedex: there were 107 reported cases of serious anaphylactic reactions due to food allergy in 2002 (in 33 children and 74 adults), including two fatalities due to soy and peanut. The prevalence of food allergy in the French population is estimated to be 3.24%.
2003  First live attenuated influenza vaccine licensed (FluMist) for use in 5 to 49 year old persons.

2003  First Adult Immunization Schedule introduced.
2003  The CDC recommended that children 6 to 23 months of age receive an annual flu vaccination. To the best of our knowledge, this is the first case of allergy to lingonberry.

Asthma increased 75% since 1980

A young woman had anaphylactic reaction that developed immediately after she kissed her boyfriend. The boyfriend had eaten several shrimp just before the kiss.

Allergy to latex rubber was almost unknown before 1980, with only two cases described in medical literature, but 8 per cent of health workers are now affected by it.
2004  Inactivated influenza vaccine recommended for all children 6 to 23 months of age.

2004  Pediarix,a vaccine that combines the DTaP, IPV, and Hep B vaccines, into one shot, is approved.
Five years - from the introduction of combination vaccines.... "The number of American children suffering from life threatening peanut allergies has doubled in the past five years and the number of Americans with food allergies has risen from 6 million to 11 million. This runs parallel with the doubling of asthma, learning disabilities, ADHD; the tripling of diabetes
2005  Boostrix and Adacel, Tdap vaccines, are approved for teens.

2005  Menactra, a new meningococcal vaccine is approved for people between the ages of 11 to 55 years of age.
  A teenage girl with an extreme allergy has died after kissing her boyfriend who had eaten a peanut-butter sandwich hours earlier. Story made world news.
2006  RotaTeq is a new rotavirus vaccine from Merck.

2006  ProQuad is a new vaccine that combines the MMR and Varivax vaccines for measles, mumps, rubella, and chicken pox into a single shot.

2006  Gardasil, the first HPV vaccine is approved.
  At the 2006 Annual Meeting of the AAAA&I in Miami,.FL., Dr Marie-Noel Primeau from the Allergy Service of Ste Justine Hospital, Montreal, presented First reaction to nuts or peanuts from candy bars labelled 'may contain nuts/peanuts' in older children.

Seal and Whale Meat: A Newly Recognized Food Allergy
2007  A booster dose of Varivax, the chickenpox vaccine, is now recommended for all children

2007  The recommended age for Flumist, the nasal spray flu vaccine, was lowered to two years.
American children were being told by government health officials and pediatricians to get 48 doses of 14 vaccines by age six and 53-56 doses of 15 or 16 vaccines by age 12. In May 2007, CNN Money reported predictions that vaccine industry sales will more than double by 2010. The Centers for Disease Control and Prevention has released the first federal study focused on childhood food allergies -- with surprising results. The study, released last month, found that the number of children with food allergies is on the rise, with an 18 percent increase of reported cases over the past decade. In 2007, about 3 million children under age 18 reported food or digestive allergies during the previous 12-month period.

First case of a sexually transmitted allergic reaction: A 20-year-old female with documented Brazil nut allergy developed urticaria and dyspnea after unprotected intercourse with her boyfriend who had earlier consumed Brazil nuts.
2008  Kinrix, a combination of DTaP and IPV that can be used for children between the ages of 4 and 6 is approved.

2008  Pentacel, a combination of DTaP, IPV and Hib is approved.

2008  Rotarix, a two dose rotavirus vaccine is approved.
Prevnar that generated US$ 2.7 Billion

global revenues already exceeding US$ 20 Billion...Vaccines are expected to fetch 20-25% more profit margins than the generics business which get 15-20% margins.
Approximately 12 million Americans suffer from food allergy, with 6.9 million allergic to seafood and 3.3 million allergic to peanuts or tree nuts.
Approximately 2.2 million school-aged children have food allergy. 18
One in every 17 children under the age of 3 has food allergy. 18
It is estimated that more than 150 people die annually from anaphylaxis to food.19
2009 H1N1 swine flu vaccine The CDC estimates that $1.6 billion was spent on the H1N1 vaccination program by the United States. H1N1 Miscarriages: Hundreds of women claim miscarriage after taking vaccine

The pharmaceutical company GlaxoSmithKline says it has advised medical staff in Canada to not use one batch of swine flu vaccine for fear it may trigger life-threatening allergies.
2010   Along with the U.S., Germany, Italy and Norway had the highest prevalence of food sensitivity -- with about 22 percent of people from each country showing antibodies against some type of food. The lowest rates were seen in Iceland (11 percent), Spain (11 percent), France and the UK (each around 14 percent).
    A generation ago, a child with an allergy was virtually unheard of.

History Timeline of Vaccines and Food Allergies: Most of the sources were from the Internet. Hover over the item to see the source. A few were from the following printed sources:

More Natural "Cures" Revealed Previously censored brand name products that cure disease, by Kevin Trudeau, Alliance Publishing Group, Inc., 2006 - page 95

1998 - Anaphylaxis after initial ingestion of rambutan, a tropical fruit
Journal of Allergy and Clinical Immunology, Volume 102, Issue 1, Pages 145-146
J.Kelso, R.Jones, J.Yunginger

2006 - Seal and Whale Meat: A Newly Recognized Food Allergy
Journal of Allergy and Clinical Immunology, Volume 117, Issue 2, Pages S45-S45
L. Moore, J. Demain, C. Sanner, B. Whisman, M. Rathkopf

2010 - The History of the Peanut Allergy Epidemic by Heather Fraser, page 131

2010 - The History of the Peanut Allergy Epidemic by Heather Fraser, page 135

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