VACCINE
CONTAINING LIVE VIRUS - Patent EP0713397
A process for preparing a purified virus
vaccine comprises the steps of
.... Such colloids
are, e.g.,
milk
(3-10%), polyvinylpyrrolidone and gelatin
...
www.freepatentsonline.com/EP0713397.html -
by LK Csatary - 2002
Broad spectrum
infectious bursal disease virus vaccine - Patent
...
The present invention provides a broad spectrum
IBDV vaccine that is able to induce
...
such as
skim
milk
(powder) is added to the water containing vaccine.
...
www.freepatentsonline.com/6485940.html -
by E Mundt - 2002
Vaccine
adjuvants comprising ginseng plant extract and added
...
Jun 14, 2005
... Thereafter, the membranes
were first incubated in a 5% dry
milk
solution followed by a 2 h incubation with sera from
vaccinated pigs diluted
...
www.freepatentsonline.com/6905712.html -
by E Rivera Vega - 2005
Use of life
attenuated bacteria for the manufacture of a
...
Use according to claim 1, characterised in that
the vaccine is for
.... agents such
as bovine serum or
skimmed milk
and buffers (e.g.
phosphate buffer).
...
www.freepatentsonline.com/EP1023903.html -
by AAC Jacobs - 2004
Plasmodium falciparum vaccine comprising a recombinant histidine ...
A vaccine comprising a
pharmaceutically acceptable adjuvant and an
....
The membrane was saturated with 5%
skim
milk powder in PBS and incubated
with
...
www.freepatentsonline.com/5393523.html -
by B Knapp - 1995
Preparation
of recombinant rotavirus proteins in milk
of
...
Preparation of recombinant rotavirus
proteins in
milk of transgenic non-human
mammals
... portfolio with
recombinant
vaccine production" BIOPROTEIN
WEBSITE,
...
www.freepatentsonline.com/EP1576877.html -
by J Cohen - 2005
Marek's
disease vaccine - Patent 5789231
The present invention is concerned with a
serotype 1 vaccine virus.
....
amino acid sources such as proteins (e.g.
milk
proteins and/or serum proteins).
...
www.freepatentsonline.com/5789231.html -
by HEM Spijkers - 1998
Recombinant
anticoccidial vaccine - Patent 5387414
An anti-coccidial vaccine
is provided which contains a recombinant peptide with
... resuspended in 200 ml of a sterile 5%
skim
milk (Difco Laboratories,
...
www.freepatentsonline.com/5387414.html -
by DE Harwood - 1995
Vaccine against gram negative bacteria - Patent 6558677 A mucosal vaccine for Neisseria based on native outer membrane vesicles (NOMV) ... The bacterial strains were stored as frozen cultures in skim milk. ...www.freepatentsonline.com/6558677.html - by WD Zollinger - 2003
http://www.nutramed.com/children/kidsmilk.htm
Cow's Milk Allergy in Children
Allergy to cow's milk is a well-studied form of food allergy.
There are
both immediate and delayed patterns of milk allergy. Immediate type
allergy tends to be obvious and shows up on skin tests. Delayed patterns of
milk allergy are not obvious, do not produce positive skin tests and tend to
cause chronic disease that is seldom diagnosed. Cow's milk contains many
proteins that are antigenic - they excite immune responses.
People of all ages with gastrointestinal tract disease may have difficulty
digesting these proteins and may absorb them as antigens. Milk problems may
be attributed to lactose intolerance and the milk-sugar enzyme, lactase, may
be prescribed. Milk allergy is a
protein problem and is not improved by changing the milk sugar -
often the diagnosis of "lactose intolerance" is incomplete or wrong and
symptoms persist with only lactose exclusion.
Beware of three cow's milk fallacies:
1. Milk allergy can be diagnosed by positive skin allergy tests
2. Lactose intolerance is the main problem with milk and can be easily
solved.
3. Infants outgrow their milk allergy; it is not common in older children
and adults
Infant milk allergy is thought to
be a specific and limited condition which children "outgrow." This idea can
be misleading -- many children continue to have chronic symptoms from milk,
although the original problem may disappear, the pattern of illness changes
and confuses parents and physicians. At the very least, we can
say that some children have an allergic tendency that persists and evolves
with different manifestations.
Milk allergy is common in adults but is seldom diagnosed.
In a follow-up study of children with immediate anaphylactic reactions to
cows milk as infants, a prolonged pattern of hypersensitivity was noted with
the development of multiple food and inhalant allergies, multiple
hospitalizations and frequent episodes of drug reactions. These children may
continue to manifest hypersensitivity and grow into adults with
immune-mediated diseases. Although there are few studies which focus on
milk-induced disease in adults, there is enough suggestive evidence to
suspect that
milk proteins
play a major role in human disease at all ages.
There are at least 30 antigenic primary proteins in milk.
Casein is the most commonly used
milk protein in the food industry; lactalbumin, lactoglobulin, bovine
albumin, and gamma globulin are other protein groups within the milk.
[And you will find these
ingredients used in vaccines!!! - bfg]
Digestion
probably increases the number of possible antigens to over 100. Milk
proteins are listed in food products with a variety of names such as milk
solids, skim milk powder, casein, caseinates, whey and albumin. Milk
proteins tend to stay intact as milk is converted to dairy products of all
types. While lactose intolerance may not be an issue with yogurt ingestion,
for example, milk protein allergy
remains. Many patients have been fooled by health claims for
lactose-free or lactaid-fixed milk and continue to have symptoms from milk
allergy when they ingest these products.
Digested fractions of each of the
milk proteins may induce the production of IgE, IgA, IgM and IgG antibodies
and may trigger complex, variable immune responses.
Skin tests with whole milk proteins are, therefore, misleading - type 1
responses do appear regularly on skin tests showing IgE activity against
intact proteins,
but
secondary antigens are not detected.
Furthermore, milk antigens tend to get through the digestive tract intact
and are therefore responsible for delayed immune responses which produce
disease in any and all tissues. These very serious immune responses do not
depend on IgE and do not show up on skin tests. The role of milk proteins in
triggering the most serious pathology usually goes undetected.
Evidence of a pathogenic
role of cows milk in many disorders has been presented - asthma, rhinitis,
eczema, urticaria, serous otitis media, pulmonary alveolitis
(hemosiderosis), milk-induced enteropathy in infants, eosinophilic
gastroenteritis, gastrointestinal bleeding with iron deficiency anemia,
migraine headaches, attention deficit hyperactivity disorder, Crohn's
disease, rheumatoid arthritis, and insulin dependent diabetes mellitus.
A major effort has been made by companies manufacturing infant formulas to
produce "hypoallergenic" milk products by various methods of protein
hydrolysis. One study showed whey hydrolysate formula reduced the incidence
of eczema in the first year of life in infants at risk; 21.8% of infants on
whey hydrolysate presented symptoms compared with 48.6%.
Formulas with
partially hydrolyzed protein have not been as 'safe" as manufacturers had
hoped and promised as Carnation found out after they marketed their "Good
Start" infant formula and many allergic reactions including anaphylaxis were
reported. In animal models, Jarret had demonstrated that small doses of
cow's milk antigens are more sensitizing than larger doses.
The IgE model of allergy
is attractive to researchers, because of its simplicity and the ease of
testing for sensitization; but, it selects only a special population of
people with Type 1, IgE-mediated allergy. While this is an important
reaction pattern, some physicians have claimed it is the only valid form of
allergic reactions to food. Their opinion is not acceptable. A distinction
between immediate, obvious allergic reactions and delayed, less obvious,
chronic immune injury is useful.
Diabetes Model
Because of evidence that cow's milk intake can trigger diabetes in rodents,
a study of diabetic children showed that antibodies to bovine serum albumin
and a 17-amino-acid bovine serum albumin peptide (ABBOS).
[Bovine serum is used as an
ingredient in vaccines. It is listed on the package insert. - bfg]
These antibodies would bind to a pancreatic beta-cell surface
antigen.
This study showed
that diabetic patients had high serum concentrations of anti-BSA antibodies
(IgA and IgG). The presence of antibody ( which
means presence of antigen-specific B-cells) may signal the concomitant
presence of antigen-specific cytotoxic T-lymphocytes, although these have
not yet be demonstrated. The researchers suggest that ... "relevant clones (
of lymphocytes) are continuously transferred from immature IgM-expressing
B-cell compartments to pools of IgG-secreting or IgA secreting cells" They
go on to describe "... a slow inefficient process, consistent with the fact
that clinical disease develops in only about 5 to 6 % of hosts with the
relevant genetic predisposition."
The diabetes model of food-antigen triggered disease is a potentially
important immunological model of many unsolved diseases which appear to be
"autoimmune". A long-term, inefficient pathogenesis which may produce
target-organ damage, especially if the antigen is provided by a common food
and intake continues over many years. Alternative explanations suggest that
beta cells are attacked by cytotoxic T-cells after they are infected by a
virus, or by T-cells originally targeted on other cells infected by virus
whose cell-surface antigens happen to resemble beta cell antigens.
An Australian study of children who developed diabetes found that children
given cows milk formula in the first three months were 52% more likely to
develop diabetes than those not fed milk. Breast fed infants had a 34% lower
incidence of diabetes than formula fed infants.
Problem Solving Example My daughter was born this past summer. She
was four weeks early and spent 11 days in an intensive care unit. After
leaving the hospital, she came home for 8 days. Then she returned to the
hospital because she was pooping a foam-like substance. The doctor
determined that she was missing the lactase enzyme because of her
prematurity and I was encouraged to continue to breast-feed, treat the milk
with lactaid drops, and feed it to her through a bottle...which I have done.
Recently we noticed blood in her stool. We saw the doctor who collected
various stool samples and blood tests, all of which came back negative. His
conclusion was that she must be allergic to the cow's milk protein. I was
put on a dairy free diet immediately, which I have now been on for over 2
weeks. I have had no milk, cheese, yogurt, ice cream, and have checked the
labels on everything. Interestingly enough, she still has blood in her
stool!!! We are frustrated!!! I guess I am wondering if I should be cutting
out beef, certain fish, eggs, or something else that may be triggering
this?? The problem is, I do not know what I can and cannot eat anymore and
no one seems to be able to give me answers. How do I keep my strength up
when there is nothing I can eat? Could this also be a wheat allergy? The
blood is bright red when it comes out and my daughter does not seem like she
is in excruciating pain....not yet, anyway. We want to find out what is
going on! She is five months old. Can you help? We tried giving her rice
cereal just before the first noticeable bleeding incident, but discontinued
that after this happened. She really only had it four times. Any help you
can give would be great!! Meal plans, suggestions, what is a milk-free diet?
Response
Cow's milk
allergy does cause intestinal bleeding in infants.
Other food allergy may contribute. You are breast feeding and
small amounts of proteins from your diet appear in your breast milk. While
milk proteins are the number 1 suspects, wheat, meat and egg proteins are
also high risk. You need to modify your diet until your daughter's symptoms
clear.
Our standard approach is to recommend that you retreat to phase 1 foods in
the Alpha Nutrition Program for more than 10 days or until your daughter's
symptoms subside completely. You would then reintroduce phase 2 foods
slowly. This is explained in the book Feeding Children and the Alpha
Nutrition Program. You can order the Children's starter pack which combines
books and some ENF formula. The formula will boost your nutrient intake.
When she is better, you can slowly introduce phase 1 foods to build a diet
for her.
Learn how you can solve food-related problems with a balanced,
scientifically-based strategy of diet revision, the Alpha Nutrition Program.
Several problems interact in a complex manner to produce the symptoms and
dysfunction that we seek to remedy.
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with proper acknowledgment of the source.
Until now, it is not an advertised fact anywhere that babies CAN be allergic to human breast milk. We have all heard of allergies to cow’s milk, where many babies are put onto soy formula. But human breast milk is thought of as the best of the best, nothing is stronger than the survival instinct and the natural drive of the new-born infant to search out the sustenance from its mother. Doctors therefore believe that it is the mother who is at fault, who is unsuccessful in her attempt to breast-feed, when the baby seems to turn its head away and scream. Two facts for you: first, human breast milk contains casein. Second, many people - as we know - are allergic to casein, causing the increase of autistic stimming and other symptoms.
casein, well-defined group of proteins found in milk, constituting about 80% of the proteins in cow's milk, but only 40% in human milk. Casein is a remarkably efficient nutrient, supplying not only essential amino acids, but also some carbohydrates and the inorganic elements calcium and phosphorus. The calcium caseinates form an insoluble white curd when acidified by hydrochloric acid or sulfuric acid, or when milk is soured by bacterial contaminants. Acid casein is used widely in cheese, adhesives, water paints, for coating paper, and in printing textiles and wallpaper. In neutral solutions the enzyme rennin converts one of the caseins to an insoluble curd; most of the protein in cheese is rennet casein curd. When treated with formaldehyde the curd forms casein plastic, used for manufacturing imitation tortoiseshell, jade, and lapis lazuli.
The Columbia Electronic Encyclopedia Copyright © 2004.Licensed from Columbia University Press
Until now, it is not an advertised fact anywhere that babies CAN be allergic to human breast milk. We have all heard of allergies to cow’s milk, where many babies are put onto soy formula. But human breast milk is thought of as the best of the best, nothing is stronger than the survival instinct and the natural drive of the new-born infant to search out the sustenance from its mother. Doctors therefore believe that it is the mother who is at fault, who is unsuccessful in her attempt to breast-feed, when the baby seems to turn its head away and scream. Two facts for you: first, human breast milk contains casein. Second, many people - as we know - are allergic to casein, causing the increase of autistic stimming and other symptoms.
To the Editor:
Immediate-type hypersensitivity to cow’s milk affects approximately 1% to 2% of young children, can persist, and can be fatal.1, 2 Vaccines against tetanus, diphtheria, and pertussis are routinely given to children in multiple doses throughout childhood. Anaphylactic reactions to these vaccines are rare and are generally attributed to the vaccine toxoids.3, 4 The US national Vaccine Adverse Events Reporting System lists 39 anaphylactic reactions to DTaP, DTP, or Tdap vaccines for patients aged 0 to 17 years from 2007-2010.5 In this period we observed 8 children in our single center with a history of anaphylactic reactions to booster doses of these vaccines. We noted that these vaccines are labeled as being processed in medium containing casamino acids (derived from cow’s milk), raising the concern that residual casein in the vaccines might have triggered these reactions. We are not aware of prior reports linking milk contamination to anaphylaxis from these vaccines. To investigate this possibility, we reviewed the medical history of the affected children and tested 8 lots of the vaccines for residual casein....
Allergic reactions have been noted to trace amounts of ingested milk protein.8, 9 We suspect that smaller injected doses, similar to insect sting–induced anaphylaxis, trigger reactions in sensitive patients because digestion is bypassed. Most children with cow’s milk allergy receive these vaccines without incident, but the patients we identified have very severe milk allergy, very high milk-specific IgE levels, and, for 4 of them, past reactions to trace milk contamination. These children tolerated their initial vaccinations but reacted to booster doses. This observation is most likely explained by increasing milk sensitivity of the children as they aged, as reflected in the personal histories of several of the children. The number of patients at our single center and their clinical features of severe milk allergy and immediate severe reactions to the vaccine argue against alternative explanations for the reactions.
http://www.jacionline.org/article/S0091-6749(11)00747-0/fulltext